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Development and Evaluation of Lornoxicam Loaded Electrospun Nanofibers for Oral Extended Release

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Nanofibers are defined as ultra fine fibers with diameters less than 100 nm. When the diameter of polymer fiber materials are shrunk from micrometer to sub micron or nanometer there appears several amazing characteristics such as very large surface area to volume ratio, flexibility in surface functionalities and superior mechanical performance compared to other known form of material. The electrospun nanofibers of lornoxicam were prepared using various polymers: PMMA, Polyethylene oxide, Gelatin and Ethyl cellulose. The FTIR studies indicated the lack of drug-polymer interaction. The SEM studies revealed the size of nanofibers was in the range of 0.4–0.8 μ. The lornoxicam release from the nanofibers was slow and extended up to 8 hours. The drug release from the optimized formulation followed first order kinetics and exhibited fickian mechanism.
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Keywords: ELECTROSPUN NANOFIBERS; EXTENDED RELEASE; LORNOXICAM

Document Type: Research Article

Publication date: August 1, 2013

More about this publication?
  • Bionanoscience attempts to harness various functions of biological macromolecules and integrate them with engineering for technological applications. It is based on a bottom-up approach and encompasses structural biology, biomacromolecular engineering, material science, and engineering, extending the horizon of material science. The journal aims at publication of (i) Letters (ii) Reviews (3) Concepts (4) Rapid communications (5) Research papers (6) Book reviews (7) Conference announcements in the interface between chemistry, physics, biology, material science, and technology. The use of biological macromolecules as sensors, biomaterials, information storage devices, biomolecular arrays, molecular machines is significantly increasing. The traditional disciplines of chemistry, physics, and biology are overlapping and coalescing with nanoscale science and technology. Currently research in this area is scattered in different journals and this journal seeks to bring them under a single umbrella to ensure highest quality peer-reviewed research for rapid dissemination in areas that are in the forefront of science and technology which is witnessing phenomenal and accelerated growth.
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