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Development of Herbal Biodegradable Polymeric Nanoparticle from Clerodendrum infortunatum L.

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Background: Clerodendrum infortunatum L. commonly known as Bhant, plays a significant role in Indian System of Medicine i.e., Ayurveda, due to its medicinal properties. It grows easily in waste places of all areas of India, Bangladesh and Myanmar. Aim: The present study was performed with a view to develop a formulation based on herbal nanoparticles to treat metabolic disorder like Hypercholesterolemia which ultimately results into a major risk factor like cardiovascular diseases, hypertension etc. Method: In this research, the petroleum ether extract of root of Clerodendrum infortunatum L. was used to formulate herbal nanoparticle and was evaluated for their surface morphology, entrapment efficiency, drug loading and surface charge. Result: Particle size of optimized batch was found to be 608 nm. Zeta potential, Drug loading and Entrapment Efficiency of optimized batch of Ether Extract was found to be –30 0 mV, 32.8% and 98.40% respectively. Conclusion: Hence, it was an attempt to make herbal polymeric nanoparticle from the ether extract of root of Clerodendrum infortunatum L. using PLGA as a polymer and hence can be used in treating hypercholesterolemia by passive targeting of nanoparticles to liver.
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Keywords: BHANT; CLERODENDRUM INFORTUNATUM L; ETHNOMEDICINE; FORMULATION DEVELOPMENT

Document Type: Research Article

Publication date: August 1, 2013

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  • Bionanoscience attempts to harness various functions of biological macromolecules and integrate them with engineering for technological applications. It is based on a bottom-up approach and encompasses structural biology, biomacromolecular engineering, material science, and engineering, extending the horizon of material science. The journal aims at publication of (i) Letters (ii) Reviews (3) Concepts (4) Rapid communications (5) Research papers (6) Book reviews (7) Conference announcements in the interface between chemistry, physics, biology, material science, and technology. The use of biological macromolecules as sensors, biomaterials, information storage devices, biomolecular arrays, molecular machines is significantly increasing. The traditional disciplines of chemistry, physics, and biology are overlapping and coalescing with nanoscale science and technology. Currently research in this area is scattered in different journals and this journal seeks to bring them under a single umbrella to ensure highest quality peer-reviewed research for rapid dissemination in areas that are in the forefront of science and technology which is witnessing phenomenal and accelerated growth.
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