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Liquid Crystalline Phthalocyanine Thin Films as Nanoscale Substrates for Protein Adsorption

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Bovine Serum Albumin (BSA) protein was adsorbed on nanoscale thick spin cast film of liquid crystalline copper octakishexylthiophthalocyanine [C6S)8PcCu]. The effect of heat treatment of films on BSA adsorption was investigated using ellipsometry, scanning electron microscopy and UV-Visible absorption spectroscopy. The ordered layer after heat treatment demonstrated quite different adsorption pattern. Heat treatment produced changes in the orientation of phthalocyanine stacks, making favourable contribution to the protein adsorption and surface coverage profile. Finally epitope presentation on bound BSAs was examined by using anti-BSA antibody.
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Document Type: Research Article

Publication date: December 1, 2008

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  • Bionanoscience attempts to harness various functions of biological macromolecules and integrate them with engineering for technological applications. It is based on a bottom-up approach and encompasses structural biology, biomacromolecular engineering, material science, and engineering, extending the horizon of material science. The journal aims at publication of (i) Letters (ii) Reviews (3) Concepts (4) Rapid communications (5) Research papers (6) Book reviews (7) Conference announcements in the interface between chemistry, physics, biology, material science, and technology. The use of biological macromolecules as sensors, biomaterials, information storage devices, biomolecular arrays, molecular machines is significantly increasing. The traditional disciplines of chemistry, physics, and biology are overlapping and coalescing with nanoscale science and technology. Currently research in this area is scattered in different journals and this journal seeks to bring them under a single umbrella to ensure highest quality peer-reviewed research for rapid dissemination in areas that are in the forefront of science and technology which is witnessing phenomenal and accelerated growth.
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