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In Vitro Cytotoxicity of Magnetic Spinel Nanoferrites (CoMgFe2O4) Against HepG2 Cells

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Nanoscience and nanotechnology have fascinated new opportunities for the formation of advance materials for use in health as well as in medical applications. Due to unique chemical and physical properties, nanoparticles e.g., magnetic nanoferrites have been very useful and shown the potential application in nanomedicine. CoMgFe2O4 nanoparticles were synthesized by Sol–gel method. Morphological analysis of said nanoparticles (NPs) was confirmed by applying SEM and XRD. The exposure of spinel ferrites to Liver cancerous cells was examined by applying multidisciplinary techniques (MTT Assay and Inverted Microscopy). The exposure of CoMgFe2O4 to liver carcinoma at 10–80 μg/ml resulted in dose-dependent cellular viability loss and provoked cell death via apoptosis. In this study, experimental results have successfully demonstrated the translocation of magnetic ferrites nanoparticles in liver carcinoma (HepG2 cell model) and ensuring the significant toxicity. The study further proposed the forthcoming therapeutic use of these nanoferrites in the cancer study.
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Document Type: Research Article

Publication date: February 1, 2018

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  • Journal of Nanoelectronics and Optoelectronics (JNO) is an international and cross-disciplinary peer reviewed journal to consolidate emerging experimental and theoretical research activities in the areas of nanoscale electronic and optoelectronic materials and devices into a single and unique reference source. JNO aims to facilitate the dissemination of interdisciplinary research results in the inter-related and converging fields of nanoelectronics and optoelectronics.
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