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Fluorescence Resonance Energy Transfer-Based Multifunctional Photonic Circuits on a Linear DNA Scaffold

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An emerging application of DNA molecule is the construction of FRET-based photonic circuits. In this system, each DNA strand is used to arrange a fluorescent molecule. To perform multi-channel input logic circuits, more fluorescent molecules were used to bind to the linear DNA scaffold. Yet it remains challenging to guarantee the energy transfer efficiency by multi-steps FRET signal cascades. To overcome this challenge, we present a two-layer logic circuit that two DNA strands are used to control a fluorescent molecule. Under the same number of input, this method can greatly reduce the number of fluorescent molecules. This circuit is successfully validated by visual DSD software. And this method may provide a new idea to design complicated biological information processing system with multi-channel input, and can be further used to control molecular systems where spatial molecular information is necessary.
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Document Type: Research Article

Publication date: October 1, 2016

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  • Journal of Nanoelectronics and Optoelectronics (JNO) is an international and cross-disciplinary peer reviewed journal to consolidate emerging experimental and theoretical research activities in the areas of nanoscale electronic and optoelectronic materials and devices into a single and unique reference source. JNO aims to facilitate the dissemination of interdisciplinary research results in the inter-related and converging fields of nanoelectronics and optoelectronics.
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