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Photodynamic Therapy Activity of Phthalocyanine-Silver Nanoparticles on Melanoma Cancer Cells

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The synthesis, characterization and photodynamic therapy activity of a novel metal free phthalocyanine (complex 3), with or without silver nanoparticles (AgNPs), are reported. The in vitro photodynamic activity of this complex was investigated using metastatic melanoma cancer cell line. In the presence of different concentrations of complex 3 or 3 in combination with silver nanoparticles, the viability of the cells showed a concentration dependent decrease upon irradiation with red light. The photodynamic activity of complex 3 showed an increase in the presence of the AgNPs. Although complex showed a high degree of aggregation in water, it still demonstrated reasonable potency towards the melanoma cancer cell line.
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Keywords: Human Skin Melanoma; Ketal; Phthalocyanine; Silver Nanoparticles

Document Type: Research Article

Affiliations: 1: Department of Chemistry, University of KwaZulu Natal, Durban, 4000, South Africa 2: Biophotonics Laboratory, National Laser Centre, CSIR, Pretoria 0001, South Africa 3: Department of Chemistry, Rhodes University, P.O. Box 94, Grahamstown, 6140, South Africa

Publication date: May 1, 2020

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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