Characterization of a Holmium 4,4′-Biphenyldicarboxylate Metal-Organic Framework and Its Potential as a Holmium Carrier System
There is growing interest in Holmium carriers for radiotherapeutic applications. In this work, a holmium-based metal-organic framework (MOF) using the 4,4′-biphenyldicarboxylic acid (H2BPDC) linker was synthesized and characterized to explore its potential as a radiotherapeutic carrier. The 3D MOF [Ho(BPDC)2]·(CH3)2NH2 was characterized by single crystal X-ray diffraction, FTIR, TGA and PXRD. A challenge to overcome in lanthanide-based MOFs is the deformation or collapse of the framework that can occur after evacuation of the pores. This structure displays high thermal stability and no collapse was observed when the molecules confined in the pores were removed. The coordination around the holmium center (CN = 8) is the key to this stability since only the organic linker and no solvent molecules coordinate to the metallic center. The porosity of the material was confirmed by high-pressure carbon dioxide (CO2) adsorption–desorption analysis. The stability of the MOF, its holmium content (28 wt%) and its porosity are features that make this material a potential holmium carrier for radiotherapeutic applications.
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Document Type: Research Article
Affiliations: Department of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX 75080-3021, United States
Publication date: May 1, 2020
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