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Synthesis of SPIONs-CNT Based Novel Nanocomposite for Effective Amperometric Sensing of First-Line Antituberculosis Drug Rifampicin

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It is necessary to study the possible interactions among various chemical surfaces and analytes before applying them to biological systems. We report the synthesis of carbon nanotubes-iron oxide (SPIONs-CNT) nanocomposite material by using lecithin stabilized superparamagnetic iron oxide nanoparticles (SPIONs) obtained by facile hydrothermal technique. Various characterizations of the obtained nanocomposite were carried out and electrochemical studies were performed further to study the interaction capabilities of the nanocomposite with anti-TB drug Rifampicin. Obtained results by cyclic voltammetric studies of SPIONs-CNT nanocomposite with limit of detection (LOD) of 1.178 μM showed the enhanced electrochemical sensitivity and selectivity of anti-tuberculosis (anti-TB) drug Rifampicin (RIF).
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Keywords: Electrochemical Biosensor; Rifampicin Detection; SPIONs-CNT Nanocomposite; Superparamagnetic Iron Oxide Nanoparticles (SPIONS); Tuberculosis

Document Type: Research Article

Affiliations: 1: Nanobiotechnology Research Group, National Institute for Biotechnology and Genetic Engineering (NIBGE), Jhang Road, Faisalabad-38000, Pakistan 2: Department of Chemistry, SBA School of Science & Engineering (SBASSE), Lahore University of Management Sciences (LUMS), DHA, Lahore Cantt, Lahore-54792, Pakistan 3: Functional Materials and Nanodevices Division, Ningbo Institute of Materials Technology and Engineering (NIMTE), Chinese Academy of Sciences (CAS), Ningbo City, Zhejiang 315201, P. R. China 4: Department of Physics, Division of Science and Technology, University of Education, Township, Lahore 54770, Pakistan 5: Department of Chemical Engineering, Northeastern University, Boston, MA-02115, USA

Publication date: April 1, 2020

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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