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Glucose Oxidase-Loaded Antimicrobial Peptide Hydrogels: Potential Dressings for Diabetic Wound

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The wound of diabetic foot is difficult to heal, and in severe cases, diabetic patients have to undergo limb amputation even after wound management. Hyperglycemia-caused vascular dysfunction and serious wound bacterial infection are the two main causes of unhealed diabetic foot ulcers. Therefore, it would be of great benefit to rescue stalled healing in diabetic wound if the blood glucose concentration can be efficiently decreased while controlling the bacterial infection in diabetic wound. Herein, we report glucose oxidase (GOx)-loaded antimicrobial peptide hydrogels and investigate their potential as diabetic wound dressings. The antimicrobial hydrogels are formed by the selfassembly of a heptapeptide (IKYLSVN) driven by intermolecular hydrogen bonding and ππ stacking interaction. The loaded GOx can convert glucose into hydrogen peroxide (H2O2), thus reducing blood glucose concentration of diabetic patients. At the same time, the produced H2O2 is antimicrobial and can combat bacterial infection in diabetic wound together with the antimicrobial hydrogels. Microscopic morphology observation of hydrogel shows uniform fibers with approximately 40 nm in size. The embedding rate can still reach 90% when the loading rate of the hydrogel loaded glucose oxidase is 12%. GOx is released by the swelling of the hydrogel based on the mechanism of free diffusion, and the cumulative release rate reaches 55%. Moreover, in vitro experiments showed that our GOx-loaded peptide hydrogel exhibits outstanding antimicrobial activity while can efficiently reduce glucose concentration of blood samples, showing great potential as promising diabetic wound dressings.
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Keywords: Antibacterial Hydrogel; Drug Release; Glucose Level Reduction; Glucose Oxidase; H2O2; Wound Dressing

Document Type: Research Article

Affiliations: 1: School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou 213164, China 2: The Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical University, Changzhou 213164, Jiangsu, P. R. China

Publication date: April 1, 2020

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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