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Thermo-Magnetic Properties of Fe3O4@Poly(N-Isopropylacrylamide) Core–Shell Nanoparticles and Their Cytotoxic Effects on HeLa and MDA-MB-231 Cell Lines

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In this study, we performed a systematic evaluation of the synthesis parameters of a multiresponsive core–shell nanoplatform (Fe3O4 nanoparticles coated by poly(N-isopropylacrylamide). These nanocomposites allow the possibility of controlling specific properties, such as particle size and morphology. The polymer coating was performed by in-situ free-radical polymerization of N-isopropylacrylamide on Fe3O4 nanoparticles to obtain a nanocomposite with a core–shell structure. We monitored the size and morphology of the nanocomposite by scanning transmission electron microscopy. Electrophoretic mobility determined the evolution of ζ-potentials during coating. We assessed the functionalization of the Fe3O4 nanoparticles by Fourier-transform infrared spectroscopy and ultraviolet-visible spectroscopy. The core–shell systems exhibited a collapsed structure when heated above the lower critical solution temperature, which was determined by dynamic light scattering. Squid based vibrating sample magnetometer tests were performed to verify superparamagnetic behavior at room temperature. The platform was approved as biocompatible for the HeLa and MDA-MB-231 cell lines by MTT assays, and it shows the desired properties for potential use in localized and controlled drug delivery.
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Keywords: LCST; Magnetite; Nanocomposites; Nanoparticles; PNIPAM; Smart Polymers; Stimuli-Responsive Polymers; Superparamagnetism

Document Type: Research Article

Affiliations: 1: Nanotechnology Graduate Program, Department of Physics, University of Sonora, Hermosillo, Sonora, 83000, Mexico 2: Department of Chemical and Metallurgical Engineering, University of Sonora, Hermosillo, Sonora, 83000, Mexico 3: Facultad de Ingeniería Mecánica y Eléctrica, Universidad Autónoma de Nuevo León, Avenida Universidad s/n, Ciudad Universitaria, C.P. 66451 San Nicolás de los Garza, N.L., México

Publication date: April 1, 2020

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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