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Synthesis of 64Cu-Radiolabeled Folate-Conjugated Iron Oxide Nanoparticles for Cancer Diagnosis

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We report the synthesis of 64Cu-labeled folate-conjugated magnetic nanoparticles for positron emission tomography (PET)/magnetic resonance imaging (MRI)-based diagnosis of cancer. The citrate/hydrazine-stabilized Fe3O4 nanoparticles measuring ~50 nm were utilized for target synthesis. Radio-thin-layer chromatography (TLC) analysis shows the formation of 64Cu-labeled nanomaterial with a radiochemical purity of 82.17% and a stability of ~90% in buffer solution and human serum for 24 h. Moreover, the sample exhibited good cellular uptake in breast (SKBR3), oral (KB) and lung (A549) cancer cell lines.
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Keywords: Biomaterials; Magnetic Materials; Nanocomposites; Nanoparticles

Document Type: Research Article

Affiliations: 1: Department of Chemistry, Dongguk University, Jung-gu, Seoul-04620, Republic of Korea 2: Materials Department, Biot Korea Inc., 43-26, Cheomdangwagi-ro, 208 Beon-gil, Buk-gu, Gwangju 61001, Republic of Korea 3: Division of Applied RI, Korea Institute of Radiological & Medical Sciences, Seoul-01812, Republic of Korea 4: Department of Printed Electronics Engineering, Sunchon National University, Sunchen-si, Jellanamdo, 57922, Republic of Korea

Publication date: April 1, 2020

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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