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Transferrin-Conjugated Superparamagnetic Iron Oxide Nanoparticles as In Vivo Magnetic Resonance Imaging Contrast Agents

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Poly(ethylene glycol) (PEG)/poly(ethylene imine) (PEI) modified superparamagnetic iron oxide nanoparticles (SPIONs) were synthesized by the thermal decomposition of iron (III) acetylacetonate (Fe(acac)3) in PEG containing PEI. Transferrin (Tf) was employed to functionalize SPIONs. The potential of Tf-SPIONs as brain magnetic resonance (MR) imaging contrast agents was explored by using Kunming mice as an animal model. The in vivo experiments revealed that Tf-SPIONs exhibited an enhanced contrast time as compared with the PEG-SPIONs and PEG/PEI-SPIONs. Tf-SPIONs exhibit promising potential for bioimaging applications because of their advantages of dispersibility in water, low cytotoxicity and long circulation time in blood.
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Keywords: MRI; Mouse Brain; SPIONs; Transferrin

Document Type: Research Article

Affiliations: 1: Key Laboratory of Nonferrous and Materials Processing Technology, Ministry of Education, College of Materials Science and Engineering, Guilin University of Technology, Guilin 541004, Guangxi, China 2: Molecular Imaging Laboratory, Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China

Publication date: April 1, 2020

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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