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Toxicological Evaluation of Graphene-Family Nanomaterials

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With the extending applications, graphene-family nanomaterials begin to enter people’s life via various ways, largely increasing the exposure frequencies. In spite of the increasing toxicological studies, the biosafety of graphene-based nanomaterials still remains elusive. Graphene oxide (GO), an oxidation derivative of graphene, is considered as one of the recently-emerging nanomaterials attractive for biomedical applications. Accompanied with the prospect of applications are the great concerns about its biosafety for human and environment. Herein, this review intends to systematically summarize the research on GO toxicity both in vitro and in vivo followed by deep discussions about the toxicological mechanisms. The currently reported toxicity of GO mainly includes inhalation toxicity, ingestion toxicity, dermal toxicity and hemocompatibility depending on exposure routes. The toxicity evaluation of GO using non-rodent organisms (zebrafish, Caenorhabditis elegans and drosophila, etc.) is also summarized, supplementary to in vivo toxicity of GO. Based on the comprehensive summary of the reported GO-induced toxicity, our review suggests considerable emphasis being put on the balance of benefits and risks when employing the nanotechnology.
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Keywords: Biosafety; Graphene Oxide; Oxidative Stress; Toxicological Mechanism

Document Type: Research Article

Affiliations: 1: College of Pharmacy, Shanxi Medical University, Taiyuan 030001, China 2: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, China 3: Jiangsu Key Laboratory of Hazardous Chemicals Safety and Control, College of Safety Science and Engineering, Nanjing Tech University, Nanjing 210009, Jiangsu, China

Publication date: April 1, 2020

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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