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Home / Journal of Nanoscience and Nanotechnology, Volume 19, Number 7

Myosin Light-Chain Kinase Inhibitors Attenuate Nanoparticles-Induced Autophagy and Cytotoxicity by Suppression Endocytosis

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Authors: Wang, Yanhong 1 ; Liu, Yiming 1 ; Zhou, Wei 2 ; Lin, Jun 3 ; Wen, Longping 1 ; 

Source: Journal of Nanoscience and Nanotechnology, Volume 19, Number 7, July 2019, pp. 3792-3797(6)

Publisher: American Scientific Publishers

DOI: https://doi.org/10.1166/jnn.2019.16324

Myosin light-chain kinase (MLCK) is a widely known kinase that controls the contraction of muscle cells. Whether MLCK is involved in the endocytosis of nanoparticles (NPs) has not been reported yet. NPs attract interest in many fields; most of them can induce autophagy and cytotoxicity after entering cells via endocytosis. In this study, we found that MLCK inhibitors, ML-7 and ML-9, abolished the endocytosis of silver NPs and yttrium oxide NPs in HeLa cells, and subsequently attenuated the autophagy induction and cytotoxicity caused by the NPs treatment. This is the first report that MLCK inhibitors acted as an endocytosis inhibitor and abolished the cell entry of NPs, which provided a new method for inhibiting the endocytosis of NPs.

Keywords: Autophagy; Endocytosis; ML-7; ML-9; Myosin Light-Chain Kinase; Nanoparticles

Document Type: Research Article

Affiliations: 1: The Chinese Academy of Sciences Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, Anhui, 230027, P. R. China 2: School of Biological and Medical Engineering, Hefei University of Technology, Hefei, Anhui, 230009, P. R. China 3: The Chinese Academy of Sciences Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, Anhui, 230027, P. R. China

Publication date: 01 July 2019

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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