Restoration Effect and Tribological Behavior of Hyaluronic Acid Reinforced with Graphene Oxide in Osteoarthritis
Osteoarthritis (OA) is an unavoidable degenerative disease of the human body. A relatively efficient and desirable treatment exists that leads to the ecological restoration of cartilage through the adjustments of the micro-environment of the human body and relies on its self-repairing
ability. In the present study, lubricants were injected into the knee joints of rats. Hyaluronic acid (HA) reinforced with graphene oxide (GO) provided a lubricating condition for cartilage repair, as well as played an important role in the regulation of the microenvironment in the joint cavity.
The experimental results demonstrated that the stability of HA lubricant reinforced with GO was dependent on the presence of oxygen-containing functional groups on the graphite oxide nano-sheets. The GO could be evenly distributed on the joint surface in the form of a solid lubrication film
and was able to decrease the articular cartilage necrosis and the ratio of MMP-3/TIMP-1 through TIMP-1 activity increase. The HA lubricant reinforced with GO demonstrated an apparent antifriction effect on the joint surface, providing a stable environment for cartilage repair. It was also
conducive to long-term lubrication improvement. The adjustment of micro-environment between the cartilage friction interfaces might contribute to the treatment of osteoarthritis through ecological restoration.
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Document Type: Research Article
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin University, Tianjin 300350, China
School of Mechanical Engineering, Hebei University of Technology, Tianjin 300130, China
January 1, 2019
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