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Flexibility and Kinesin Affinity of Paclitaxel Stabilized Microtubule Under the Influence of GHz Electric Fields: A Molecular Modeling Approach

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Paclitaxel, one of the cancer chemotherapy drugs, stabilizes microtubule (MT) and changes its physical properties. Alteration in physical properties of MT and affinity of its associated motor proteins, such as kinesin, may be used as an effective approach in cancer treatment. In this paper, simultaneous influences of paclitaxel and oscillating GHz electric fields on flexibility of MT and on kinesin affinity to αβ-tubulin have been investigated, via using molecular dynamics simulation method. To approach to these purposes, a designed system consists of two αβ-tubulin stabilized by paclitaxel (SP αβ-tubulin) was exposed to electric fields in 1–10 GHz frequency range to examine MT flexibility. Then, another designed system was considered to study kinesin affinity to SP αβ-tubulin in three different structures, containing ATP, ADP and none of them. It was found that application of such fields changes flexibility of MT and changes kinesin affinity to SP αβ-tubulin. This variation in MT flexibility and kinesin affinity, due to the application of such fields, may perturb cancer treatment process, using paclitaxel.
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Keywords: GHz Electric Fields; Kinesin Affinity; Molecular Dynamics; Paclitaxel Stabilized αβ-Tubulin

Document Type: Research Article

Affiliations: 1: Queensland Micro-and Nanotechnology Center, Griffith University, Nathan, 4111, Brisbane, Australia 2: Department of Physics, University of Isfahan, P.O. Box 81746-73441, Isfahan, Iran

Publication date: November 1, 2018

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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