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Magnetic Lamellar Nano-Hydroxyapatite as a Vector for Gene Transfection in Three-Dimensional Cell Culture

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Compared to two-dimensional (2D) conditions, investigation on gene transfection in three-dimensional (3D) conditions is much less extensive. In this work, lamellar nano-hydroxyapatite (L-HAp) with and without magnetism were used as the vectors and gene transfection in 2D and 3D cell culture was carried out and compared. We found that the transfection efficiency in 3D conditions was much higher than 2D cell culture. Additionally, magnetism enhanced transfection efficiency under both 2D and 3D conditions. The findings presented in this study demonstrated that the magnetic L-HAp could be a promising vector in 3D gene transfection.
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Keywords: Gene Transfection; Hydroxyapatite; Layered Materials; Magnetic Materials; Three-Dimensional Environment

Document Type: Research Article

Affiliations: 1: School of Materials Science and Engineering, East China Jiaotong University, Nanchang 330013, China 2: Hebei Provincial Key Laboratory of Inorganic Nonmetallic Materials, College of Materials Science and Engineering, North China University of Science and Technology, Tangshan 063009, China

Publication date: August 1, 2018

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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