Thermo-Sensitive PLGA-PEG-PLGA Tri-Block Copolymer Hydrogel as Three-Dimensional Cell Culture Matrix for Ovarian Cancer Cells
Thermo-sensitive hydrogels which could encapsulate cells and provide a three dimensional (3D) microenvironment have great potential in building new cell culture models in vitro. In this study, a thermal responsive hydrogel based on PLGA-PEG-PLGA tri-block copolymers was developed
as matrix for 3D ovarian cancer cell culturing. The gelation of PLGA-PEG-PLGA tri-block copolymer was concentration-dependent. SEM images showed the pores were suitable for the formation of 3D cell structures. Cell morphological results showed that large aggregates of ovarian cancer cells
(HO8910) were formed after cultured for 10 days. Therefore, hydrogel based on PLGA-PEG-PLGA tri-block copolymers hold potential as in vitro cell culture matrix for ovarian cancer cells.
Keywords: 3D Cell Culture; Ovarian Cancer Cell; PLGA-PEG-PLGA; Thermo-Sensitive Hydrogel
Document Type: Research Article
Affiliations: 1: State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, National Demonstration Center for Experimental Biomedical Engineering Education, School of Biological Sciences and Medical Engineering, Southeast University, Nanjing 210096, China 2: Key Lab of Clinical and Medical Engineering, Department of Biomedical Engineering, School of Basic Medical Sciences, Nanjing Medical University, Nanjing 211166, China
Publication date: 01 August 2018
- Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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