Preliminary Study for Measurement of Shear Stress and Hemocompatibility Using Commercialized Lab on a Chip
We have investigated the effect of flow rate on shear stress and in turn thrombus formation on a lab-on-a-chip with a microchannel that is suitable for cell culture and growth. Using a combination of Arduino UNO, Arduino Motor Shield, and a SERVO stepper motor, we created a pump system
that closely mimics the in vivo conditions of the human body. With this system, we achieved continuous flow of blood and observed attached platelets at the bottom of the collagen coated microslide, confirming that with shear stress, thrombus formation increases.
Keywords: Arduino; Collagen; Lab-on-a-Chip; Platelet Aggregation; Shear Stress; Thrombosis
Document Type: Research Article
Affiliations: 1: Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju, Korea 2: Department of Neurosurgery, Research Institute of Clinical Medicine, Chonbuk National University Medical School and Hospital, Jeonju, Korea
Publication date: 01 February 2018
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