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In Situ Synthesis of Chitosan Coated Silver-Zinc Oxide Nanocomposites and Its Enhanced Antibacterial Properties

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The burgeoning antibiotic resistance of the bacteria has encouraged the researchers globally to develop new antimicrobial agents. Herein, we have developed nanocomposites (NCs) by coating chitosan (ch) onto the silver-zinc oxide nanocomposites through microwave assisted In Situ approach, obtaining [email protected] NCs as a novel biopolymer coated antimicrobial agent. The surface morphology, crystalline structure and the functional groups of the nanocomposites were characterized by using field emission scanning electron microscopy (FE-SEM), X-ray diffraction measurements (XRD) and Fourier transform infrared spectroscopy (FTIR). The minimum inhibitory concentration (MIC) and the minimum killing concentration (MKC) of the [email protected] NCs showed excellent antibacterial activity towards both Gram-positive bacteria Staphylococcus aureus (S. aureus) and Gram-negative bacteria recombinant green fluorescent protein (GFP) expressing antibiotic resistant Escherichia coli (E. coli). Further investigation of the antibacterial activity against the live water samples revealed that the [email protected] NCs treatment exhibited the similar antibacterial efficacy by inhibiting the bacterial growth. Also the MKC value of [email protected] NCs against S. aureus and GFP E. coli was 30 μg/mL and 300 μg/mL, respectively. Compared to the silver and zinc oxide based nanocomposites which have been widely used as antibacterial agents, our chitosan coated [email protected] NCs exhibited better antibacterial efficacy. Therefore, we proposed that the polymer coated metal-metal oxide nanocomposites is quite a promising antibacterial agent, suitable for the water purification applications.
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Keywords: Antibacterial Agents; Chitosan; Nanocomposites; Water Disinfection

Document Type: Research Article

Affiliations: Nanobiotechnology Laboratory, Centre for Nanotechnology

Publication date: December 1, 2017

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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