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Synthesis and In Vitro/In Vivo Evaluation of Gd-Complex Utilizing Dendritic Ligands as a Magnetic Resonance Contrast Agent

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We demonstrate a dendritic Gd(III)-DTPA derivative [Gd-DTPA-tris(2-aminoethyl)amine-D2-4Glc(OH)], containing glycoside moieties, for magnetic resonance imaging contrast agents. In vitro relaxometry and in vivo MRI studies show that the novel Gd complex can be a potential candidate for a contrast agent because of the enhanced relaxivity and tissue-selectivity, compared to the Gd(III)-DTPA complex. Thus, we envision that the dendritic modification, employed in this work, provides insight into the design of a promising candidate for novel medical contrast agents.
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Keywords: Gd-Dendrite Complex; In Vivo Evaluation; MR Imaging; MRI Contrast Agents

Document Type: Research Article

Affiliations: 1: Department of Chemistry, HOD of Humanities and Sciences, Golden Valley Institute of Technology, Madanapalle 517325, India 2: Transportation Environmental Research Team, Korea Railroad Research Institute, Uiwang 16105, Korea 3: Bioimaging Research Team, Korea Basic Science Institute, Cheongju 28119, Korea 4: Department of Chemistry and Green-Nano Materials Research Center, Kyungpook National University, Daegu 41566, Korea 5: Department of Chemistry, College of Life Science and Nano Technology, Hannam University, Daejeon 34430, Korea

Publication date: August 1, 2017

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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