The present work has been focused on the fabrication and characterization of amphiphilic chitosan nanoparticles by oil-in-water emulsion/ionic gelation technique. We elucidated the successful encapsulation of nanoparticles by FT-IR spectroscopy technique, and determined the shape, morphology
and mean particle size by SEM and laser light scattering, respectively. The size of nanoparticles was about 103.5 nm by SEM and 373.95 ± 12.8 nm by laser light scattering. The novelty of this study is the evaluation of various factors (crosslinking pH, crosslinker, and core and shell
materials ratio) on encapsulation efficiency, loading capacity and release of a hydrophobic drug model such as letrozole. Encapsulation efficiency, loading capacity and release behavior of letrozole were affected by the factors. In vitro drug release studies showed an initial burst
followed by a slow drug release. The amphiphilic chitosan nanoparticles prepared under lower pH and higher concentration of crosslinker agent resulted in slower letrozole release from nanoparticles. Under these conditions we observed that the release of letrozole was decreased when the concentration
of core/shell materials was increased and the best release value was obtained when the concentration of core/shell materials was identical.
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Amphiphilic Chitosan Nanoparticles;
Document Type: Research Article
Department of Biology, Faculty of Science, Razi University, Kermanshah, 67149, Islamic Republic of Iran
Faculty of Chemistry, Sensor and Biosensor Research Center (SBRC) and Nanoscience and Nanotechnology Research Center (NNRC), Razi University, Kermanshah, 67149, Islamic Republic of Iran
August 1, 2017
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