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Preparation of Amphiphilic Chitosan Nanoparticles for Controlled Release of Hydrophobic Drugs

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The present work has been focused on the fabrication and characterization of amphiphilic chitosan nanoparticles by oil-in-water emulsion/ionic gelation technique. We elucidated the successful encapsulation of nanoparticles by FT-IR spectroscopy technique, and determined the shape, morphology and mean particle size by SEM and laser light scattering, respectively. The size of nanoparticles was about 103.5 nm by SEM and 373.95 ± 12.8 nm by laser light scattering. The novelty of this study is the evaluation of various factors (crosslinking pH, crosslinker, and core and shell materials ratio) on encapsulation efficiency, loading capacity and release of a hydrophobic drug model such as letrozole. Encapsulation efficiency, loading capacity and release behavior of letrozole were affected by the factors. In vitro drug release studies showed an initial burst followed by a slow drug release. The amphiphilic chitosan nanoparticles prepared under lower pH and higher concentration of crosslinker agent resulted in slower letrozole release from nanoparticles. Under these conditions we observed that the release of letrozole was decreased when the concentration of core/shell materials was increased and the best release value was obtained when the concentration of core/shell materials was identical.
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Keywords: Amphiphilic Chitosan Nanoparticles; Chitosan; Cross Linker; Hydrophobic Drug; Palmitic Acid

Document Type: Research Article

Affiliations: 1: Department of Biology, Faculty of Science, Razi University, Kermanshah, 67149, Islamic Republic of Iran 2: Faculty of Chemistry, Sensor and Biosensor Research Center (SBRC) and Nanoscience and Nanotechnology Research Center (NNRC), Razi University, Kermanshah, 67149, Islamic Republic of Iran

Publication date: August 1, 2017

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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