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Sensitivity Analysis in 3D Manipulation of Biological Nanoparticles

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Computer simulations to predict the motion of nanoparticles had been developed for Atomic Force Microscopy (AFM) based robots. The proposed model includes a system of coupled nonlinear equations which determine the system dynamics. As biological nanoparticles are fragile by nature, it is important to apply the exact amount of pressure during manipulation process. Therefore, the sensitivity analysis simulation has been performed to study the effects of inflectional parameters. Using derivative sensitivity analysis, the effects of geometrical (particle and cantilever shapes), process (user defined) and environmental parameters have been investigated and the most influential parameters have been introduced. The simulations provide a real-time platform and make the biological nanoparticles positioning more practical.
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Keywords: AFM; Biological Nanoparticles; Manipulation; Sensitivity Analysis

Document Type: Research Article

Affiliations: 1: Robotic Research Laboratory, Center of Excellence in Experimental Solid Mechanics and Dynamics, School of Mechanical Engineering, Iran University of Science and Technology, Tehran, 16846-13114, Iran 2: Faculty of Industrial and Mechanical Engineering, Islamic Azad University, Qazvin Branch, Qazvin, 34199-15195, Iran 3: Department of Biology and Applied of Life Science, Gyeongsang National University, Jinju 660-701, Republic of Korea 4: School of Mechanical and Aerospace Engineering, Gyeongsang National University, Jinju 660-701, Republic of Korea

Publication date: August 1, 2017

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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