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Synthesis of Surface Grafted Mesoporous Magnetic Nanoparticles for Cancer Therapy

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A comparative study has been done on the drug loading efficacy of different surface functionalized Fe3O4 magnetic nanoparticles (MNP) and their effect toward ovarian cancer cell line (HeLa) in vitro. The surface coating was done with carboxyl group enriched organic ligands such as succinic acid, L-arginine, oxalic acid, citric acid and glutamic acid. A maximum of ~62 wt.% drug has been loaded in oxalic acid coated MNP whereas least (~35 wt.%) in arginine coated MNP due to variation in the chemistry of surface active agents. The cytotoxicity of functionalized MNP and doxorubicin loaded MNP were studied. The functionalized MNP are quite biocompatible whereas they show cytotoxic effect in HeLa cells e.g., around 35% cell death when treated with oxalic acid coated MNP at a concentration of ~100 μg/ml. The cell death was triggered in drug loaded particle and almost complete cell death i.e., >90% was observed in oxalic acid coated MNP followed by ~80% and ~70% death in arginine and succinic acid coated MNP, respectively.
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Keywords: Cancer; Doxorubicin; Iron Oxide; Mesoporous; Surface Active Agents

Document Type: Research Article

Affiliations: 1: Centre for Nanotechnology Research, VIT University Vellore 632014, India 2: School of Bioscience and Technology, VIT University Vellore 632014, India 3: Department of Chemical Engineering, IIT Bombay, Mumbai 400076, India

Publication date: August 1, 2017

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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