A Novel Fullerene-Based Drug Delivery System Delivering Doxorubicin for Potential Lung Cancer Therapy
We developed an attractive method to prepare a fullerene-based (C82) drug delivery system modified with doxorubicin (DOXO) and cyclic RGD motif (DOXO-C82-cRGD) for potential clinic use treating solid tumors, lung cancers. The DOXO-C82-cRGD nanoparticles with a diameter of ~1.7 nm were
prepared and the chemical structure was confirmed with MALDI-TOF, dynamic light scattering (DLS), and X-ray photoelectron spectroscopy (XPS). The DOXO-C82-cRGD nanoparticles showed great stability in phosphate buffer solution (PBS) and were also stable in low concentration of thiols (20 μM).
On the contrary, the high concentration of thiols (10 mM) remarkably enhanced the deconjugation of DOXO-C82-cRGD. The in vitro results demonstrated that DOXO-C82-cRGD nanoparticles showed great preferential cellular uptake in non-small lung cancer cells as compared with DOXO-C82 and
particularly, DOXO. Moreover, the cell viability results suggested that DOXO-C82-cRGD had significant cytotoxicity to cells at low dose. Apparently, the DOXO-C82-cRGD nanoparticles showed strong in vitro anti-tumor ability. Our study certainly provide a novel drug delivery system for
preparing DOXO-contained vehicles for solid tumor therapy in clinic.
Keywords: C82; Doxorubicin; Drug Delivery; Lung Cancers
Document Type: Research Article
Affiliations: College of Pharmacy, Jinzhou Medical University, Jinzhou 121001, China
Publication date: 01 August 2017
- Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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