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Home / Journal of Nanoscience and Nanotechnology, Volume 17, Number 3

Inhibitory Effects of Free and Nano-Liposomal-Loaded Resveratrol on Sodium Nitroprusside-Induced Rabbit Chondrocyte Apoptosis

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Osteoarthritis (OA) is a progressive and functionally debilitating disease characterized by chondrocyte apoptosis. Resveratrol (RV, trans-3,4,5-trihydroxystilbene), a natural polyphenol compound with anti-inflammatory, has anti-OA activity. In this study, RV was loaded to nanoliposomes to form nomolipsome-RV complex (Lip-RV) which had good solubility and bioavailability. Exposure of chondrocytes to sodium nitroprusside (SNP) resulted in remarkable reactive oxygen species (ROS) generation and apoptosis. Cell viability assay, cell apoptosis detection and mitochondrial membrane potential analysis revealed that both free RV and Lip-RV remarkably suppressed SNP-induced cytotoxicity toward chondrocytes, and the protective activity of free RV was better than that of Lip-RV. We further studied the effects of free RV and Lip-RV on SNP-induced chondrocyte morphological change and generations of H2O2, iron ions and ROS, and found that free RV exhibited more protective effect than Lip-RV against SNP-induced oxidative damage and iron ions production. In conclusion, free RV has more profound in vitro protective effect on SNP-induced chondrocyte apoptosis than Lip-RV.

Keywords: Apoptosis; Chondrocyte; Nanoliposome-Resveratrol; ROS

Document Type: Research Article

Affiliations: 1: Department of Pain Management, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, P. R. China 2: School of Biological Science and Medical Engineering, State Key Laboratory of Bioelectronics, Southeast University, Nanjing 211189, P. R. China 3: MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, P. R. China

Publication date: 01 March 2017

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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