Bovine Serum Albumin Coated Upconversion Nanoparticles for Near Infrared Fluorescence Imaging in Mouse Model
The unique properties of upconversion nanoparticles (UCNPs) facilitate them to be good candidates for cell and animal imaging. In our work, we developed a facile approach to synthesize nano-composites which is composed of UCNPs and bovine serum albumin (BSA). The nano-composites (UCNPs@BSA)
exhibited dual fluorescence in the visible range and NIR range simultaneously. The low cytotoxicity of UCNPs and UCNPs@BSA was demonstrated in L02 and HepG-2 cell lines respectively. The cell imaging investigations verified the biological imaging capability of UCNPs@BSA. Furthermore, UCNPs@BSA
displayed favorable in vivo imaging capability in tumor-bearing mice. Consequently, the dual fluorescence emission probe was demonstrated to be a promising candidate for cell and tumor imaging.
Keywords: Cell Imaging; Low Biotoxicity; Near Infrared Fluorescence; Upconversion Nanoparticles; in vivo Imaging
Document Type: Research Article
Affiliations: 1: Department of Biomedical Engineering, School of Engineering, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjia Lane, Gulou District, Nanjing 210009, China 2: Jiangsu Provincial Center for Disease Control and Prevention, Department of Occupational Health, Qixia District, Nanjing 210028, China 3: School of Pharmacy, China Pharmaceutical University, 24 Tongjia Lane, Gulou District, Nanjing 210009, China
Publication date: 01 February 2017
- Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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