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Bovine Serum Albumin Coated Upconversion Nanoparticles for Near Infrared Fluorescence Imaging in Mouse Model

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The unique properties of upconversion nanoparticles (UCNPs) facilitate them to be good candidates for cell and animal imaging. In our work, we developed a facile approach to synthesize nano-composites which is composed of UCNPs and bovine serum albumin (BSA). The nano-composites ([email protected]) exhibited dual fluorescence in the visible range and NIR range simultaneously. The low cytotoxicity of UCNPs and [email protected] was demonstrated in L02 and HepG-2 cell lines respectively. The cell imaging investigations verified the biological imaging capability of [email protected] Furthermore, [email protected] displayed favorable in vivo imaging capability in tumor-bearing mice. Consequently, the dual fluorescence emission probe was demonstrated to be a promising candidate for cell and tumor imaging.
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Keywords: Cell Imaging; Low Biotoxicity; Near Infrared Fluorescence; Upconversion Nanoparticles; in vivo Imaging

Document Type: Research Article

Affiliations: 1: Department of Biomedical Engineering, School of Engineering, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjia Lane, Gulou District, Nanjing 210009, China 2: Jiangsu Provincial Center for Disease Control and Prevention, Department of Occupational Health, Qixia District, Nanjing 210028, China 3: School of Pharmacy, China Pharmaceutical University, 24 Tongjia Lane, Gulou District, Nanjing 210009, China

Publication date: February 1, 2017

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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