Cytotoxic Effect of Oleanolic Acid-Coated Magnetic Nanoparticles on Reversal of Multidrug Resistance in A549 Lung Cancer Cells
In this study, oleanolic acid-coated magnetic nanoparticles (OMP) were synthesized, and their cytotoxicity in the form of their ability to reverse multidrug resistance in A549 lung cancer cells was evaluated. Fe2O3 magnetic nanoparticles (MNPs), approximately 23
nm in diameter, were prepared using a chemical co-precipitation method and coated with two surfactants to yield a water-based product. The average diameter of the OMP was 40 nm. The characteristics of the particles were determined by X-ray diffraction, field emission scanning electron microscopy,
and energy-dispersive X-ray spectroscopy. MTT assay showed that OMP inhibited the growth of both A549 cells and oleanolic acid-resistant A549 cells in a dose-dependent manner, and that this inhibition was enhanced with the use of MNPs. The rate of apoptosis in the OMP group was higher than
that in the control group and in the MNP group, as determined by flow cytometry. Our results demonstrated the biological applicability of OMP as anticancer agents and as agents for enhanced drug delivery against human lung cancer cells.
Keywords: Anti-Tumor Activity; Drug Delivery; Magnetic Nanoparticles; Oleanolic Acid
Document Type: Research Article
Affiliations: 1: Department of Advanced Materials Engineering, Daejeon University, Daejeon, 34520, Korea 2: Department of Computer Science and Engineering, Sunmoon University, Asan, 31460, Korea 3: Department of Pathology, Daejeon University College of Oriental Medicine, Daejeon, 34520, Korea 4: Division of Food Bioscience, Konkuk University, Chungju, 27478, Korea
Publication date: 01 October 2016
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