Design of Curcumin Loaded Polymeric Nanoparticles-Optimization, Formulation and Characterization
The role of Curcumin for treatment of diseases like colon cancer, pancreatic cancer, arthritis and Alzheimer’s disease has become the area of growing interest. It has a low intrinsic toxicity and magnificent properties like anti-inflammatory, anti-mutagenic, anti-oxidant, with
comparatively lesser side-effects. However, because of its poor solubility, low absorption and poor bioavailability, they are not efficient to be used for clinical purposes. Formation of nanoparticles proved very much promising to increase absorption and bioavailability, leading to the effective
drug administration. In this study curcumin encapsulated polymeric nanoparticles are prepared to enhance bioavailability of the hydrophobic drug. Two methods of preparation of nanoparticles are explored—(a) a conventional precipitation method and (b) rapid precipitation method using
Multi Inlet Vortex Mixer (MIVM). The particles from both the methods are purified using rotavap and dried by hot-air oven or lyophilizer. Nanoparticles with well-defined properties were obtained using MIVM. An optimization study was done to obtain desired particle size. Dynamic light scattering
showed the particle sizes were between 150–400 nm. The Differential Scanning Calorimetry (DSC) results showed that the drug in the nanoparticles was in the amorphous state. From the analysis, Fourier Transform Infrared Spectroscopy (FTIR), stability and intactness of entrapped drug in
the nanoparticles was shown. The drug loading in the nanoparticles was in the range of 19–23 wt%. The drug from the nanoparticle showed higher solubility compared to the pure as-received drug.
Keywords: CMCAB; Curcumin; MIVM; Nanoparticles; Rapid Precipitation; Simple Precipitation
Document Type: Research Article
Affiliations: Department of Chemical Engineering, Birla Institute of Technology and Science, Pilani 333031, Rajasthan, India
Publication date: 01 September 2016
- Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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