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Home / Journal of Nanoscience and Nanotechnology, Volume 16, Number 7

Drug Delivery Properties of Nano-Bundles Formed In Vitro by Janus-Type TA Nucleosides

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In this study, the potential of nano-bundles formed by Janus-type thymidine-adenosine (J-TA) nucleosides as a new drug delivery system was investigated. Preliminary In Vitro stability and biocompatibility tests indicated that the nano-bundles were stable and had low cytotoxicity. The water-insoluble and anti-cancer drug, honokiol (HK), was used as a model to determine the efficiency of this new drug carrier. Results from scanning electron microscopy and ultraviolet-visible spectroscopy indicated that HK was successfully incorporated into the nano-bundles in water. Finally, drug-release experiments showed that release of HK from the nano-bundles was effectively achieved, suggesting that nano-bundles self-assembled by J-TA nucleosides could represent a potential drug delivery system for water-insoluble drugs.

Keywords: Drug Delivery; Janus-Type; Nano-Bundles; Nucleoside; Self-Assembly

Document Type: Research Article

Affiliations: 1: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China 2: Institute for Nanobiomedical Technology and Membrane Biology, Regenerative Medicine Research Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, China

Publication date: 01 July 2016

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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