Facile One-Pot Preparation of Silver/Reduced Graphene Oxide Nanocomposite for Cancer Photodynamic and Photothermal Therapy
Photodynamic therapy (PDT) and photothermal therapy (PTT) have shown promise in treatment modality for various malignant diseases. In this report, an one-pot and green synthesis approach has been employed to prepare silver/reduced graphene oxide (Ag/rGO) nanocomposite as a new kind
of anticancer drug, in the presence of sodium hydroxide at 70 °C. The prepared Ag/rGO hybrids were characterized by transmission electron microscopy; X-ray diffraction, ultraviolet-visible spectroscopy, and Fourier transform infrared spectroscopy. Cell culture, cytotoxicity and phototoxicity
assay were tested using MCF-7 human breast cancer cell. Results suggest that, a homogeneous distribution of silver nanoparticles (∼12 nm) on rGO sheets. The as-prepared Ag/rGO nanocomposite can serve as an integrated system for combined photodynamic therapy and photothermal therapy.
Keywords: Ag/rGO Nanocomposite; MCF-7 Cell; Photodynamic Therapy; Photothermal Therapy
Document Type: Research Article
Affiliations: 1: School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China 2: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China 3: School of Physics and Engineering, Zhengzhou University, Zhengzhou 450001, China
Publication date: 01 July 2016
- Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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