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Electrodynamics of DNA Molecules Moving Through Microfluidic Channels Studied with Single Molecular Fluorescence Imaging Technology

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Flow dynamic features of single DNA molecules moving within micro/nano-channels have become significant for they can be widely used in stretching, separation and development of high-speed DNA molecules sequencing technology. In this study, the electrodynamics’ properties of -DNA molecules which were transferred through microfluidic channels and driven by electric field force, were studied using single molecule fluorescence imaging technology. Results indicated that the velocity of DNA molecules moving within the microfluidic channels was critically dependent on the value of applied electric field, and their direction was commonly opposite to the direction of electric field. A particularly intriguing phenomenon was that the direction of DNA molecules moving within the 30 μm channels was reversed at a threshold voltage, i.e., E 0 = 7 × 103 V/m, which was induced by competition between the electrophoresis effects and elecroosmosis. The microfluidic mechanisms were finally discussed.
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Keywords: Electrodynamic Properties; Electroosmosis; Electrophoresis; Surface Modification

Document Type: Research Article

Affiliations: 1: Institute of Photonics and Photo-Technology, International Scientific and Technological Cooperation Base of Photoelectric Technology and Functional Materials and Application, Northwest University, Xi’an 710069, China 2: Mechanical Engineering Department and Biomedical Engineering Program, University of South Carolina, Columbia 29208, USA

Publication date: July 1, 2016

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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