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Fabrication of the Optical Fiber GABA Sensor Based on the NADP+-Functionalized Quantum Dots

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A novel quantum dots (QDs)-based optical fiber biosensor has been developed to detect γ-amino butyric acid (GABA) directly, via QD fluorescence quenching and recovery. QDs were immobilized on the surface of an optical fiber through the EDC/Sulfo-NHS coupling reaction. The QDs were functionalized by 3-aminophenyl boronic acid and then by NADP+. The fluorescence of the NADP+-functionalized QDs was quenched by electron transfer from QDs to NADP+. However, by the metabolic conversion of GABA to succinic acid by GABase, NADP+ was reduced to NADPH, which hindered the electron transfer. As a result, the fluorescence of the QDs could recover. The recovery rate of the fluorescence intensity of QDs depended on the concentration of GABA. This shows the possibility of detection of low concentrations of GABA via measurement of the fluorescence intensity.
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Document Type: Research Article

Publication date: February 1, 2016

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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