Bioactivity of Cellulose Acetate/Hydroxyapatite Nanoparticle Composite Fiber by an Electro-Spinning Process

Hydroxyapatite/cellulose acetate composite webs were fabricated by an electro-spinning process. This electro-spinning process makes it possible to fabricate complex three-dimensional shapes. Nano fibrous web consisting of cellulose acetate and hydroxyapatite was produced from their mixture solution by using an electro-spinning process under high voltage. The surface of the electrospun fiber was modified by a plasma and alkaline solution in order to increase its bioactivity. The structure, morphology and properties of the electro-spun fibers were investigated and an in-vitro bioactivity test was evaluated in simulated body fluid (SBF). Bioactivity of the electro-spun web was enhanced with the filler concentration and surface treatment. The surface changes of electrospun fibers modified by plasma and alkaline solution were investigated by FT-IR (Fourier Transform Infrared Spectroscopy) and XPS (X-ray Photoelectron Spectroscopy).