Carboxymethyl Dextran-Cyclodextrin Conjugate as the Carrier of Doxorubicin
The carboxymethyl dextran- γ -cyclodextrin (CMD- γ CD) conjugate was prepared as the carrier for the delivery of the poorly water-soluble anticancer drug, doxorubicin (DOX). The conjugate could form self-assembled nanoparticles (315 nm in diameter) in an aqueous solution, which might be due to the hydrogen bonding among γ CD molecules in the conjugate. DOX was effectively encapsulated into CMD- γ CD nanoparticles (CMD-NPs) by the emulsion method. In particular, regardless of the feed amount of DOX, its loading efficiencies were always greater than 70%. CMD-NPs released DOX in a sustained manner, owing to the inclusion complex formation between DOX and γ CD. When Cy5.5-labeled CMD-NPs were treated with SCC7 cancer cells, strong fluorescence signals were observed at the cytosol, indicating effective intracellular uptake. In addition, DOX-loaded CMDNPs exhibited dose-dependent cytotoxicity to SCC7 cancer cells. However, the empty nanoparticles did not show toxicity to the cells, implying their high biocompatibility. Overall, these results suggest that the CMD- γ CD conjugate could be a useful carrier for the delivery of DOX.
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Document Type: Research Article
Publication date: November 1, 2013
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