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Synthesis of Hydroxyapatite Nanoparticles with Tailorable Morphologies and Carbonate Substitutions Using a Wet Precipitation Method

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Hydroxyapatite (HA) nanoparticles with different morphologies and variant levels of carbonate substitutions were synthesized using a wet precipitation method by adjusting the heating temperature and/or the initial ion concentration of the reaction system. Within the particles, crystalline domains with different lengths were aligned along each other and formed into nanoparticles with different sizes, shapes and topographies. Different from most reported studies, the nucleation, growth and morphology of the crystalline domains were found sensitive to heating temperature, but not significantly influenced by initial ion concentration within the studied range. The OH and PO3− 4 ions within the HA particles were partially substituted by CO2− 3 ions. The substitution was dominated by the replacement of OH instead of PO3− 4 in HA. The carbonate substitution was found to decrease with increasing heating temperature and/or initial ion concentration. Therefore, both the morphology and composition of the HA particles can be tailored by controlling the heating temperature and/or the initial ion concentration in the reaction system. Such synthesized HA nanoparticles can be used as biomaterials for bone tissue engineering.
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Document Type: Research Article

Publication date: March 1, 2012

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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