RecA Protein Mediated Nano-Scale Patterning of DNA Scaffolds
Molecular lock-and-key functionality inherent to a large number of biological molecules is arguably one of the most promising potential routes for building complex nanostructures and eventually nanoelectronic devices by self-assembly. Here, we report the use of the DNA-binding protein RecA as a tool for patterning DNA scaffolds site-specifically and in a programmable way at the nanometrescale. This is demonstrated by patterning a 3 kilo-base-pair double-stranded DNA molecule at ten different locations with nanometre-sized RecA-based nucleoprotein filaments. This protein-based molecular patterning technique, which is site-specific, programmable, and scalable, offers a potential basis for molecular lithography applications, and opens previously inaccessible routes towards the fabrication of complex functional nano-electronic devices by self-assembly.
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Document Type: Research Article
Publication date: December 1, 2011
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