Response of Fetal Rat Calvarial Cells to Nanotubular Titanium Oxide Surface
This study examined the cell response to a TiO2 nanotubular surface (Ti–NT) for future biomedical applications. The level of cell attachment and spreading at 20 min and 60 min was evaluated by SEM. IL-6 and PGE2 secretion was evaluated by ELISA. In SEM analysis, the Ti–NT surface had more fully spread cells compared to the machined titanium surface (Ti–S). ELISA revealed that the level of IL-6 and PGE2 production was higher on the Ti–NT than on the Ti–S. These results suggest that a surface treatment with a nanotubular TiO2 surface enhances the early osteoblast responses, such as cell spreading and cytokine release, which are important for subsequent cell functions and bone healing in vivo.
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Document Type: Research Article
Publication date: February 1, 2011
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