Enhanced Anti-Cancer Effect of 5-Fluorouracil Loaded into Thermo-Responsive Conjugated Linoleic Acid-Incorporated Poloxamer Hydrogel on Metastatic Colon Cancer Models
Conjugated linoleic acid-coupled Pluronic F127 (Plu-CLA) is an effective drug delivery system with numerous advantages and anti-cancer activity. 5-FU administered in Plu-CLA hydrogel (P-FU) led to the significant enhancement of tumor growth suppression and cellular apoptosis. Moreover, growth of hepatic and intraperitoneal metastases in vivo was significantly reduced in mice treated with P-FU. Therefore, Plu-CLA could be a potential intraperitoneal carrier for hydrophilic 5-FU for the effective treatment of metastatic colon cancer.
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Document Type: Research Article
Publication date: February 1, 2011
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