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Simultaneous Determination of 3,4-Dihydroxyphenylacetic Acid, Uric Acid and Ascorbic Acid by Poly(L-Arginine)/Multi-Walled Carbon Nanotubes Composite Film

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The poly(L-Arginine)(PArg)-multiwalled carbon nanotubes (MWCNTs) composite film was used to modify glassy carbon electrode (GCE) to fabricate PArg/MWCNTs/GCE through electropolymerization of L-Arginine on MWCNTs/GCE. The PArg/MWCNTs/GCE exhibited high electro-catalytic activities towards the oxidation of 3,4-dihydroxyphenylacetic acid (DOPAC), uric acid (UA), and ascorbic acid (AA), and could be sensitively used for simultaneous determination of DOPAC, AA, and UA in pH 7.4 phosphate-buffered solution (PBS). The linear ranges were 7 μM to 2.7 mM for DOPAC, 3 μM to 1.2 mM for UA, and 70 μM to 1.4 mM for AA. The detection limits were 1.3 μM for DOPAC, 0.7 μM for UA and 20 μM for AA.
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Keywords: 3,4-DIHYDROXYPHENYLACETIC ACID; ASCORBIC ACID; MULTI-WALLED CARBON NANOTUBES; POLY(L-ARGININE); URIC ACID

Document Type: Research Article

Publication date: February 1, 2011

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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