A Novel Drug and Gene Co-Delivery System Based on Poly(-caprolactone)-Poly(ethylene glycol)-Poly(-caprolactone) Grafted Polyethyleneimine Micelle
In this paper, we prepared a novel cationic self-assembled micelle from poly(-caprolactone)-poly(ethyl glycol)-poly(-caprolactone) grafted polyethyleneimine (PCEC-g-PEI). The PCEC-g-PEI micelles, formed by self-assembly method, had mean particle size of ca. 82 nm and zeta potential of +22.5 mV at 37 °C, and could efficiently transfer pGFP into HEK293 cells in vitro. Meanwhile, as a model hydrophobic chemotherapeutic drug, honokiol was loaded into PCEC-g-PEI micelles by direct dissolution method assisted by ultrasonication. The honokiol loaded cationic PCEC-g-PEI micelles could effectively adsorb DNA onto its surface, while it could release honokiol in an extended period in vitro. This study demonstrated a novel DNA and hydrophobic chemotherapeutic drug co-delivery system.
Keywords: GENE DELIVERY; HONOKIOL; MICELLE; POLY(EPSI-CAPROLACTONE)-POLY(ETHYLENE GLYCOL)-POLY(EPSI-CAPROLACTONE); POLYETHYLENEIMINE; SELF-ASSEMBLY
Document Type: Research Article
Publication date: 01 December 2010
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