Functionalization of Carbon Nanotubes with Bovine Serum Albumin in Homogeneous Aqueous Solution
Single-walled (SWNTs) and multiple-walled (MWNTs) carbon nanotubes were solubilized via the esterification of nanotube-bound carboxylic acids by oligomeric polyethylene glycol compounds. The water-soluble samples were used as starting materials in reactions with bovine serum albumin (BSA) protein in ambient aqueous solutions. The reaction conditions were designed for thermodynamically favorable transformation from ester to amide linkages, yielding SWNT-BSA and MWNT-BSA conjugates. The results show that the use of soluble starting nanotube materials in an indirect functionalization method represents a valuable approach to the biomodification of carbon nanotubes.
Keywords: Bioconjugates; Bovine Serum.; Carbon Nanotube; Indirect Functionalization; Protein; Water-soluble
Document Type: Communications
Affiliations: 1: Department of Chemistry and Center for Advanced Engineering Fibers and Films, Howard L. Hunter Chemistry Laboratory, Clemson University, Clemson, South Carolina, USA 2: Department of Chemistry and Center for Advanced Engineering Fibers and Films, Howard L. Hunter Chemistry Laboratory, Clemson University, Clemson, South Carolina, USA 3: Department of Chemistry, Furman University, Greenville, South Carolina, USA 4: Department of Physics and Astronomy, Kinard Laboratory, Clemson University, Clemson, South Carolina, USA
Publication date: 01 October 2002
- Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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