1H-MRS Analysis for Prefrontal Cortex, Hippocampus and Thalamus of Adolescent Patients with Depression
Objective: To explore the change of neural biochemical metabolite level in prefrontal cortex, hippocampus and thalamus of adolescent patients with depression. Methods: 1H-MRS technology was utilized to quantitatively analyze the levels of NAA, Cho, Glx, (Cr2,
Cr) and mI in the cerebrum. Results: Compared with control group, the NAA/Cr values of depression group both in bilateral prefrontal cortex and hippocampus tissue were much lower (P < 0.01 or P < 0.05). The Cho/Cr values of depression group in bilateral prefrontal
cortex were higher (P < 0.05 or P < 0.01). The Glx/Cr values of right frontal lobe and right hippocampus were lower (P < 0.05), and the differences were significant. The mI/Cr values of right hippocampus were higher (P < 0.05). Comparison of all the
metabolite levels in thalamus between the depression group and control group, the differences were not significant (P > 0.05). Conclusions: Prefrontal cortex and hippocampus were the main affected parts during the process of disease for adolescent patients with depression.
And NAA had the most significantly positive relation with depression. 1H-MRS could obtain enough neurochemical change information from the body with the non-invasive method when depression occurs, which provides a new research thought for the micro change in brain tissue of adolescent
depression patient in essence.
Keywords: 1H-MRS; ADOLESCENT DEPRESSION; HIPPOCAMPUS; METABOLIC SUBSTANCES; PREFRONTAL CORTEX; THALAMUS
Document Type: Research Article
Publication date: 01 November 2015
- Journal of Medical Imaging and Health Informatics (JMIHI) is a medium to disseminate novel experimental and theoretical research results in the field of biomedicine, biology, clinical, rehabilitation engineering, medical image processing, bio-computing, D2H2, and other health related areas.
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