Synthesis, X-ray Characterization and Antimicrobial Activity of (3-(4-bromophenyl)oxiran-2-yl)(2,4-dichlorophenyl)methanone
(3-(4-bromophenyl)oxiran-2-yl)(2,4-dichlorophenyl)methanone 2 was synthesized via treating of 3-(4-bromophenyl)-1-(2,4-dichlorophenyl) prop-2-en-1-one 1 with hydrogen peroxide in the presence of sodium hydroxide in a mixture from acetone and methanol with stirring. The
structure and purity of the synthesized product was confirmed by elemental analysis, IR, nuclear magnetic resonance (1H NMR and 13C NMR), mass spectroscopy and X-ray single crystal. The obtained compound 2 was screened as antimicrobial activity compared to Streptomycin
and Fusidic acid as reference drugs.
Keywords: (3-(4-BROMOPHENYL)OXIRAN-2-YL)(2,4-DICHLOROPHENYL)METHANONE; ANTIMICROBIAL ACTIVITY; X-RAY SINGLE CRYSTALS
Document Type: Research Article
Publication date: 01 February 2018
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