Synthesis and Antimicrobial Evaluation of a Series of Novel Imidazole Acyclic Nucleoside Analogues
A new series of imidazole acyclic nucleosides linked pyrene moiety have been synthesized by alkylation of (5Z)-5-(pyren-2-ylmethylidene)-2-sulfanyl-3,5-dihydro-4H-imidazol-4-one with different sugar halides. All the new compounds were investigated for their in vitro
antimicrobial activities and among them slight were found to be highly efficient antibacterial agents. In the same time, almost all the tested compounds exhibited amazing antifungal activity against Aspergillus niger strain which showed higher activity (18.17–25.23) than the reference
drugs Neomycin and Nystatin (15.15).
Keywords: ACYCLIC NUCLEOSIDES; ANTIMICROBIAL ACTIVITY; IMIDAZOL-4-ONE DERIVATIVES
Document Type: Research Article
Publication date: 01 October 2017
- Journal of Computational and Theoretical Nanoscience is an international peer-reviewed journal with a wide-ranging coverage, consolidates research activities in all aspects of computational and theoretical nanoscience into a single reference source. This journal offers scientists and engineers peer-reviewed research papers in all aspects of computational and theoretical nanoscience and nanotechnology in chemistry, physics, materials science, engineering and biology to publish original full papers and timely state-of-the-art reviews and short communications encompassing the fundamental and applied research.
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