Potent Anticancer and mTOR Inhibitor Activities of Some Synthesized Linear and Macrocyclic Pyridine Derivatives
A series of linear and macrocyclic 2,6-disubstituted pyridine derivatives 1–7 were previously prepared and evaluated as analgesic and anticonvulsant agents. Herein these derivatives were screened as anti pancreatic cancer, anti-GIT cancer and mTOR inhibitor activities. The tested
compounds were found to have in vivo and in vitro potent anti-pancreatic cancer and anti-GIT cancer activities. The mechanism of action of these compounds was evaluated as mTOR inhibitors.
Keywords: 2,6-Disubstituted Pyridine; Anti-GIT Cancer; Anti-Pancreatic Cancer; Leniar and Macrocyclics Derivatives; mTOR Inhibitors
Document Type: Research Article
Affiliations: 1: Pharmaceutical Chemistry Department, Drug Exploration and Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia 2: Research Unit, Saco Pharm. Co., 6th October City 11632, Egypt
Publication date: 01 January 2017
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