Research on the Synthesis and Characterization of Sitafloxacin
The convenient protocol for the synthesis of Sitafloxacin form Ethyl 3-(3-chloro-2,4,5-trifluorophenyl)-3-oxopropanoate with tri-ethyl ortho-formate and (1R, 2S)-(-)-cis-1-2-fluorine cyclopropane amino-p-toluene sulfonic acid salt by condensation under sodium hydrogen condition was
well described in this research. After hydrolysis of ester in hydrochloric acid solution, derivative product reacted with (S)-N-((oxoboryl) methylene)-5-azaspiro[2,4]heptan-7-amine by condensation. Total conversion of 52-65% for Sitafloxacin was accomplished. The structure of Sitafloxacin
was characterized by 1H NMR, 13C NMR, IR, MS and elemental analysis.
Keywords: Condensation; Sitafloxacin; Structure
Document Type: Research Article
Affiliations: 1: Xuzhou College of Industrial Technology, 221140 Jiangsu Xuzhou, China 2: Graduate Institute of Environmental Management, Tajen University, 90741, Taiwan
Publication date: 01 September 2016
- Journal of Computational and Theoretical Nanoscience is an international peer-reviewed journal with a wide-ranging coverage, consolidates research activities in all aspects of computational and theoretical nanoscience into a single reference source. This journal offers scientists and engineers peer-reviewed research papers in all aspects of computational and theoretical nanoscience and nanotechnology in chemistry, physics, materials science, engineering and biology to publish original full papers and timely state-of-the-art reviews and short communications encompassing the fundamental and applied research.
- Editorial Board
- Information for Authors
- Submit a Paper
- Subscribe to this Title
- Terms & Conditions
- Ingenta Connect is not responsible for the content or availability of external websites
- Access Key
- Free content
- Partial Free content
- New content
- Open access content
- Partial Open access content
- Subscribed content
- Partial Subscribed content
- Free trial content