Quantitative Structure Activity Relationship Study for Development of Plasmin Inhibitors Controlled by the Spacer Hydantoin
The aim of these work present in this paper consisted in the development and evaluation of the quantitative structure activity relationships (QSAR) for the prediction of the Plasmin inhibition by Hydantoin derivatives, whereas Plasmin is a proteolytic enzyme that is formed from plasminogen
in blood plasma and dissolves the fibrin in blood clots. The compounds used are potent inhibitors of the Plasmin which could, explain its role in inhibiting tumor growth. Various physicochemical descriptors were used in multiple linear regressions method (MLR) to develop the theoretical models,
than using a cross-validation with leave-one-out method to optimize the model as well as possible to fit with the biological data.
Document Type: Research Article
Publication date: 01 October 2015
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