Schizophrenia Candidate Genes Specific to Human Brain Region are Restricted to Basal Ganglia
Gene expression profiles produced by Microarray present a potential method for exploring the relationship between genes and brain. Here we analyzed the human gene expression levels among eight brain regions, including frontal lobe, Insula, limblic lobe, occipital lobe, parietal lobe, temporal lobe, basal ganglia and other cerebral nuclei. Top 45 schizophrenia candidate genes (179 probes) expression levels were compared between each two of these regions. 73.3% gene (88.3% probe) expressed differently from one region to others at least. Strikingly, 66.7% gene (83.2% probe) expression in basal ganglia distinguished from other regions. The great variation of the schizophrenia candidate gene expression in different brain regions indicated there is different neuropathologic mechanisms regulated by these candidate genes to this disease and basal ganglia would be the expression center of schizophrenia candidate genes.
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Document Type: Research Article
Publication date: November 1, 2014
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