Skip to main content
padlock icon - secure page this page is secure

Schizophrenia Candidate Genes Specific to Human Brain Region are Restricted to Basal Ganglia

Buy Article:

$106.34 + tax (Refund Policy)

Gene expression profiles produced by Microarray present a potential method for exploring the relationship between genes and brain. Here we analyzed the human gene expression levels among eight brain regions, including frontal lobe, Insula, limblic lobe, occipital lobe, parietal lobe, temporal lobe, basal ganglia and other cerebral nuclei. Top 45 schizophrenia candidate genes (179 probes) expression levels were compared between each two of these regions. 73.3% gene (88.3% probe) expressed differently from one region to others at least. Strikingly, 66.7% gene (83.2% probe) expression in basal ganglia distinguished from other regions. The great variation of the schizophrenia candidate gene expression in different brain regions indicated there is different neuropathologic mechanisms regulated by these candidate genes to this disease and basal ganglia would be the expression center of schizophrenia candidate genes.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics

Keywords: BASAL GANGLIA; GENE EXPRESSION PROFILE; HUMAN BRAIN; SCHIZOPHRENIA

Document Type: Research Article

Publication date: November 1, 2014

More about this publication?
  • Journal of Computational and Theoretical Nanoscience is an international peer-reviewed journal with a wide-ranging coverage, consolidates research activities in all aspects of computational and theoretical nanoscience into a single reference source. This journal offers scientists and engineers peer-reviewed research papers in all aspects of computational and theoretical nanoscience and nanotechnology in chemistry, physics, materials science, engineering and biology to publish original full papers and timely state-of-the-art reviews and short communications encompassing the fundamental and applied research.
  • Editorial Board
  • Information for Authors
  • Submit a Paper
  • Subscribe to this Title
  • Terms & Conditions
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more